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) Pipeline Insight - Upper GI Disorders - Generics will limit
Gastroesophageal reflux disease (GERD), functional dyspepsia (FD) and peptic ulcer disease (PUD) represent a group of common gastrointestinal (GI) conditions, which can be referred to collectively as upper GI disorders. Gastric acid suppression remains the cornerstone of therapy in upper GI disorders, with particular focus on reducing symptoms and eradicating H. pylori, if present. Scope Analysis of patient potential, unmet needs and . More>> - (
) Is ineffective oesophageal motility associated with
IEM is associated with an increased acid clearance times in the distal oesophagus. Gastropharyngeal reflux causes supraoesophageal manifestations such as globus, chronic cough, hoarseness, asthma, chronic sinusitis, or other otorhinolaryngologic diseases. It might be hypothesised that patients with IEM would be unable to clear refluxed acid; this would lead to a prolonged oesophageal dwell time of the refluxed acid and then the refluxed acid would reach to a higher level. As a result, it would be presumed that patients with IEM have more gastropharyngeal reflux than those patients with normal oesophageal motility.A research article published on 21 October 2008 in the World Journal of Gastroenterology addresses this question. The research team led by Prof. Kim from Pusan National University Hospital evaluated the association between IEM and gastropharyngeal reflux in a large series of patients who underwent ambulatory 24-hour dual-probe pH monitoring for the evaluation of supraoesophageal symptoms. More>>
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) Former Walkerton woman follows strict diet to control IBS
I ended up having acid reflux and IBS (irritable bowel syndrome)," said Seidle, 25, who now lives in the neighbouring community of Hanover.I still have IBS and I will probably have it forever. I can't eat anything hot or too much citrus. I can't have much pop anymore. It's just funny how certain things send certain people off," she said in a telephone interview Thursday.
Her story could soon be a familiar one to victims of an E. coli outbreak linked to a Harvey's restaurant in North Bay.
People should be reassured, over time the symptoms will dissolve," said Dr. Bill Clark, lead investigator in the new Walkerton Health Study.
The seven-year study of thousands of people in Walkerton, which was devastated in May 2000 by an E. coli outbreak due to contaminated water, looked at renal disease, diabetes and irritable bowel syndrome. More>>
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) LifeCoach: Our experts answer questions
A: Gastroesophageal reflux disease (Gerd) or acid reflux disease occurs when the valve which separates the stomach and the tube leading into it (the oesophagus), does not close properly and allows acid from the stomach to back up into the oesophagus causing the burning sensation known as heartburn. Avoid trigger foods such as spicy meals, high fat or acidic foods (such as citrus fruits and tomatoes), caffeine and chocolate. Alcohol and excessive amounts of vitamin C from supplements can also stimulate gastric acid secretion, making symptoms worse, as do fizzy drinks. Also avoid large meals, especially at bedtime: don’t lie down for an hour after meals and try not to eat or drink for two to three hours before going to bed. It is better to have smaller meals throughout the day and to eat slowly. More>>